CBD is a potent anti-inflammatory substance. Inflammation is often a consequence of damage to tissue. Inflammation is a problem in various ailments. In rheumatism for example, there is inflammation in the joints.
In several studies with mice it has been found that both CBD and THC (depending on dosage) have an impact on the production and release of certain cytokines. Cytokines play an important role in in the immune system and its response to inflammation. CBD can have both an inhibitory as well as a stimulating effect on these cytokines. For example, CBD inhibits the release of interleukin 17 (IL17) . This pro-inflammatory cytokine is more active than normal in certain diseases (such as MS). In the same study it is also observed that CBD promotes the production of IL-10. In contrast to IL17, this cytokine has anti-inflammatory properties.
A study that researched the effect of CBD on rheumatoid arthritis also examined cytokines . In the mice that had received CBD it was found that the production of inflammatory cytokines was inhibited by CBD. This thereby also inhibited the progression of the disease.
Other studies also found an anti-inflammatory effect of CBD in mice. These results were found for: acute pancreatitis (inflammation of the pancreas)  and acute injury to the lung .
The medical world has great interest in CBD as a potential new drug against diseases in which inflammation plays a role. Although THC seems to have similar anti-inflammatory effects as CBD, CBD is regarded more interesting because it doesn’t have a psychoactive effect.
Advice for using CBD against inflammation
If you are already taking medication for inflammation, consult your doctor first. Probably CBD can be used in combination with other medication. If you plan to use CBD, you can opt for a CBD-containing oil. CBD is a safe drug, you can experiment with the dose until you reach the desired effect. It is also possible to use CBD for preventing inflammation. Click here to read more about safe use of cannabinoids.
- Kozela, E., Juknat, A., Kaushansky, N., et al. (2013). Cannabinoids decrease the th17 inflammatory autoimmune phenotype. J Neuroimmune Pharmacol, 8(5): 1265-76.
- Malfait, A.M., Gallily, R., Sumariwalla, P.F., et al. (2000). The nonpsychoactive constitutent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America, 97: 9561-9566
- Li, K., Feng, J.Y., Li, Y.Y., et al. Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice. Pancreas, 42(1): 123-9
- Ribeiro, A., Ferraz-de-Paula, V., Pinheiro, M.L., et al. Cannabidiol, a nonpsychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. Eur J Pharmacol, 678: 78-85