Appetite (stimulating or inhibiting appetite)

Posted | 4 comments


In cancer, HIV, anorexia or obesity

 

The appetizing effect of the cannabinoid THC is well known, especially for those who use cannabis recreationally. In a study of Sofia and Knobloch other cannabinoids seem to have just the opposite effect on appetite [1]. This study examined the effect of CBD and CBN on food and sugar consumption. What was found was that animals that received a dose of CBD or CBN consumed less food. This effect was observed up to 5 days following administration of CBD and CBN. It must be noted though, that the sugar intake decreased to a much lesser extent, which suggests that the test animals had developed a preference for sweet foods.

On the other hand, there are also subsequent studies that suggest that CBD and CBN stimulate appetite [2,3] or that they have little influence on appetite. What should be noted though, is that these studies often used much lower dosages of CBD and CBN. All in all, the scientific research provides a mixed picture and we must conclude that cannabinoids can surely affect appetite, we just do not yet know exactly how this works.

 

We know for some time that THC can increase appetite. This makes THC a good candidate to induce appetite in diseases in which this is a problem. Cancer and HIV are probably the most obvious ailments, but THC may be used for anorexia as well. The biggest problem with THC is probably the psychoactive effect (getting high or stoned). People who want to use THC as medicine are generally not looking for this effect (as opposed to recreational users) and often find it unpleasant. Combined use with CBD could offer a solution. It is known fact that CBD counteracts some of the unwanted psychoactive effects of THC. By combining THC with CBD, higher doses of THC may be tolerated better.

 

Advice for the use of cannabinoids in problems with appetite

Cannabinoids can stimulate appetite as well as inhibit it. THC is known for stimulating appetite. The effects of CBD and CBN seem to be more complex and are likely to be dose-dependent. To use cannabinoids against obesity, experiment with the dose and evaluate the effects of different doses on you personally. If you wish to arouse appetite, THC may be an option. If you want to counteract the psychoactive effects of THC at the same time, you can use CBD (and possibly CBN) in combination with THC. You’ll probably have to experiment to find the right dose in this case as well. If you are already in treatment for any of the ailments discussed in this article, consult your doctor or specialist first. Click here to read more about safe use of cannabinoids.

 

 

References

  1. Sofia, R.D., Vassar, H.B., and Knobloch, L.C. (1976). Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats. Pharmacology Biochemistry & Behavior. 4: 591-599.
  1. Farrimond, J.A., Whalley, B.J., and Williams, C.M. (2012b). Non-∆⁹ tetrahydrocannabinol phytocannabinoids stimulate feeding in rats. Behavioral Pharmacology, 23: 113-117
  1. Scophino, A.A. , Guimarães, F.S., Corrêa, F.M., and Resstel, L.B. (2011). Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1 A receptor agnonists. Pharmacology Biochemistry & Behavior, 98: 268-272.

 

Weblinks

  1. http://www.ncbi.nlm.nih.gov/pubmed/951436
  1. http://centaur.reading.ac.uk/28007/
  1. http://www.ncbi.nlm.nih.gov/pubmed/21238476

 

 

4 Comments

  1. Ik heb 7 weken CBD olie gebruikt in een lage dosering van 2,75%. Wel nam ik ongeveer 21 a 45 druppels per dag. Het is mij opgevallen dat ik meer eetlust kreeg toen ik de olie gebruikte. Dit verdween weer toen ik stopte.
    Ik gebruikte de olie ivm chronische pijn, dit hielp mij niet.

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    • Hoi janne, voor je chronische pijn zou ik hogere cbd adviceren zeker 25 procent. Mijn moeder heeft er veel baat bij. Wij zijn lang op zoek geweest voor goede hogere cbd en betaalbaar. Die hebben we gevonden bij Dutchnaturalhealing. Zoek maar op via google…. misschien heb je hier wat aan.
      Groetjes clau

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  2. Hoi Ik ben een vrouw 52 jaar 186cm en weeg maar 66 kilo Ik heb weinig eetlust. Ik krijg wel eetlust van cannabis. Maar ik kom er niet van aan.en dat wil ik wel graag
    Dus ik wil vragen Kom ik aan met cdb? Zo ja hoeveel kilo in hoeveel tijd?ook last van epilepsie en reuma (RA) hydradenitis. Hartkloppingen (mitralisprolaps) ben in 3 maanden 7 kilo afgevallen. Heb alles na laten kijken.bij de internist Maar geen afwijkingen gevonden hoop van jullie te horen
    Mvg BB

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    • Beste Bep,
      Dank voor je vraag! Vervelend dat je in een korte tijd zoveel bent afgevallen. Van CBD zelf kom je niet aan (net als dat je van de THC in cannabis niet aan komt). Mogelijk dat CBD in sommige gevallen de eetlust kan stimuleren, maar dit effect is in ieder geval minder duidelijk dan bij THC/cannabis. We zijn bang dat als het stimuleren van eetlust (met THC/cannabis) het probleem bij jou niet verhelpt, CBD ook niet zal werken.
      We zien momenteel geen oorzaak/oplossing voor je probleem vanuit onze hoek, vervelend dat de medici die ook (nog) niet zien!

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